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ORIGINAL ARTICLE
Year : 2018  |  Volume : 1  |  Issue : 1  |  Page : 12-16

Association between polymorphisms in genes regulating Vitamin A metabolism and kidney size in Indian Newborns


1 Division of Molecular Medicine, St. John's Research Institute, Bengaluru, Karnataka, India
2 Department of Radiology, St. John's Medical College Hospital, Bengaluru, Karnataka, India
3 Division of Molecular Medicine, St. John's Research Institute; Department of Pediatric Nephrology, St. John's Medical College Hospital, Bengaluru, Karnataka, India

Correspondence Address:
Anil Vasudevan
Department of Pediatric Nephrology, St. John's Medical College Hospital, Bengaluru, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/AJPN.AJPN_6_18

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Introduction: Previous studies suggest that maternal serum vitamin A levels and polymorphisms in genes regulating vitamin A metabolism may impact fetal kidney development. Information on these genetic variations is limited to Caucasian population. Methods: This prospective observational single center study included newborns of 349 pregnant women enrolled at 8 weeks of gestation. Kidney volumes were measured at birth by ultrasound and cord blood was tested for single nucleotide polymorphisms (SNPs) in genes encoding for aldehyde dehydrogenase 1 family member A2rs7169289, cellular retinoic acid binding protein-2rs12724719, receptor tyrosine kinasers1800860, retinol-binding proteinrs11187540, and the Vitamin A receptor stimulated by retinoic acid 6rs17852249. Results: The total (left + right) kidney volume, unadjusted and adjusted for body surface area at birth, was 21.5 ± 4.6 ml and 107.3 ± 20.7 ml/m2, respectively. Single nucleotide polymorphisms (SNPs) in genes encoding for proteins regulating vitamin A metabolism were not associated with kidney volume at birth. Conclusions: Polymorphisms in genes involved in vitamin A metabolism are not associated with kidney size in Indian newborns.


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