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BRIEF REPORT
Year : 2019  |  Volume : 2  |  Issue : 2  |  Page : 94-97

Role of renal doppler spectral study in detecting allograft dysfunction in early post-transplant period


1 Department of Pediatric Nephrology, St. John's National Academy of Health Sciences, Bengaluru, Karnataka, India
2 Department of Radiology, St. John's National Academy of Health Sciences, Bengaluru, Karnataka, India

Correspondence Address:
Ramya Vedula
50-1-40/14/2, F202, Sridevi Residency, Apseb Colony, Seethammadhara, Visakhapatnam - 530 013, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/AJPN.AJPN_13_19

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Doppler sonography is routinely used to assess global and segmental perfusion abnormalities in renal allograft. However, its utility in distinguishing between the causes of allograft dysfunction is unclear, and information is lacking on the outcomes of allografts with abnormal findings. In this single center study, we retrospectively reviewed the records of pediatric allograft recipients who underwent Doppler spectral study within 3 weeks of transplantation. Resistive index (RI) of >0.7 was considered abnormal. Serum creatinine at the time of Doppler and at 3-month follow-up was documented. Among 34 children transplanted over 5 years, delayed graft function (DGF) was observed in 36% of allografts. RI was significantly higher for allografts with DGF than those without DGF (0.85 ± 0.17 vs. 0.69 ± 0.10; P = 0.004). Serum creatinine was significantly higher for allografts with abnormal than normal Doppler. However, there was no significant association between RI and the underlying histopathology. RI at the level of segmental (r = 0.62) and arcuate arteries (r = 0.55) correlated well with serum creatinine. Allografts with high and normal RI had comparable serum creatinine at 3-month follow-up (median [interquartile range] 0.65 [0.6, 0.9] vs. 0.7 [0.65, 0.8]; P = 0.98).


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