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Year : 2019  |  Volume : 2  |  Issue : 1  |  Page : 36-40

Pediatric acute poststreptococcal glomerulonephritis: A single-center experience

1 Pediatric Nephrology Center of Excellence; Department of Pediatrics, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
2 Department of Pediatrics, Children Hospital, Ministry of Health, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Kingdom of Saudi Arabia
3 Department of Pediatric, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
4 King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Kingdom of Saudi Arabia

Correspondence Address:
Jameela A Kari
Pediatric Nephrology Center of Excellence, Department of Pediatrics, King Abdulaziz University, Jeddah
Kingdom of Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/AJPN.AJPN_6_19

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We evaluated the frequency, severity, and outcome of children with acute poststreptococcal glomerulonephritis (PSGN) by retrospectively reviewing case records of all children diagnosed with PSGN between 2007 and 2015. The diagnosis of PSGN was based on the evidence of recent streptococcal infection, including positive streptococcal culture from the skin or throat, high or rising antistreptolysin O titer (>333 IU/ml), or high anti-deoxyribonuclease B level (>200 IU/ml). In addition, low serum complement 3 level and/or kidney biopsy results were considered. Children with evidence of chronic kidney disease (CKD) were excluded from the study. Sixty-six children (50 boys) with age 8.4 ± 3.4 years were included in the study. Ninety percent of the children had proteinuria and 79% had impaired glomerular filtration rate at presentation. One child had rapidly progressive glomerulonephritis. At 1-year follow-up, 10% of the children had renal impairment, 25% had hypertension, and 40% had proteinuria. As a considerable percentage of patients with PSGN in this series had CKD at 1-year follow-up, careful prolonged follow-up of such patients is advisable.

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