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Year : 2020  |  Volume : 3  |  Issue : 1  |  Page : 10-14

Cystatin C as a biomarker of acute kidney injury in sick neonates

Department of Pediatrics, ESI PGIMSR, Basaidarapur, Delhi, India

Correspondence Address:
Sweta Kumari
Department of Pediatrics, ESI PGIMSR, Basaidarapur, Delhi - 110 015
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/AJPN.AJPN_29_19

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Objective: This study was planned to study serum cystatin C (CysC) levels in sick neonates admitted in neonatal intensive care unit (NICU) with predisposing risk factor(s) for development of acute kidney injury (AKI). We evaluated serum levels of CysC and creatinine in sick neonates. Methods: Ninety-four sick neonates with prematurity, sepsis, respiratory distress, and/or perinatal asphyxia requiring NICU admission were enrolled. Serum levels of creatinine and CysC were measured on day 3 of life. Results: Serum levels of both cystatin C and creatinine were significantly elevated in neonates who developed AKI versus those who did not (CysC: 2.18 ± 0.59 vs. 1.91 ± 0.47 mg/dl, P = 0.04; creatinine: 1.68 ± 0.75 vs. 0.89 ± 0.40, P < 0.001). Levels of CysC were elevated in sick neonates with risk factors of developing AKI. Conclusions: Serum levels of CysC are elevated in sick neonates at risk of AKI. CysC is a useful indicator of risk of AKI in ill neonates.

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