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BRIEF REPORT
Year : 2020  |  Volume : 3  |  Issue : 2  |  Page : 71-74

Takayasu arteritis with ANCA associated vasculitis and anti-GBM antibodies


1 Department of Pediatrics, All India Institute of Medical Sciences, Raebareli, Uttar Pradesh, India
2 Department of Radiodiagnosis, Sikund Diagnostic Centre, Dehradun, Uttarakhand, India
3 Department of Renal Pathology, National Reference Laboratory, Dr Lal Path labs Ltd, New Delhi, India
4 Department of Pediatrics, SGRR Institute of Medical Sciences, Dehradun, Uttarakhand, India

Correspondence Address:
Mritunjay Kumar
Department of Pediatrics, All India Institute of Medical Sciences, Raebareli - 229 405, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2589-9309.305901

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Vasculitides are conventionally classified according to the size of the vessels involved and characteristic clinical and histopathological findings. Anti-neutrophil cytoplasmic antibodies (ANCAs) and other serologies help characterizing small vessel vasculitis. While few cases of large vessel involvement are reported in association with ANCA-associated vasculitis, these reports were in adult patients and lacked typical large vessel involvement. We describe an adolescent girl with focal necrotizing glomerulonephritis and positive serologies for p-or myeloperoxidase ANCA, as well as large vessel arteritis and presence of anti-glomerular basement membrane antibodies. This report highlights the diagnostic difficulties in rare patients presenting with overlap in clinical and serological features of different forms of systemic vasculitis.


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