| BRIEF REPORT |
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| Year : 2021 | Volume
: 4
| Issue : 1 | Page : 30-32 |
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Late effect of chemotherapy for osteosarcoma on kidney function
Takuji Enya, Tomoki Miyazawa, Kohei Miyazaki, Naoki Sakata, Keisuke Sugimoto
Department of Pediatrics, Faculty of Medicine, Kindai University, Osaka-Sayama, Japan
Correspondence Address:
Takuji Enya
Department of Pediatrics, Faculty of Medicine, Kindai University, 377-2 Ohno-Higashi, Osaka-Sayama 589-8511
Japan
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/AJPN.AJPN_29_20
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With improvement in the outcomes of chemotherapy, the management of late effects of chemotherapy is an increasingly important concern in patients with osteosarcoma. However, the risk factors for late effects on kidney function are not clear. We report seven cases of osteosarcoma, including three patients with severe or recurrent drug-induced acute kidney injury, who were diagnosed with tubulointerstitial nephritis after the treatment of osteosarcoma. Although late renal effects are considered to be dose-dependent, they are not invariable with the same protocol. The severity and frequency of acute kidney injury following chemotherapy might have influenced the occurrence of renal late effects.
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