Asian Journal of Pediatric Nephrology

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 3  |  Issue : 1  |  Page : 10--14

Cystatin C as a biomarker of acute kidney injury in sick neonates


Jyoti Bagla, Sweta Kumari, Raksha Gupta, Iqra Khan 
 Department of Pediatrics, ESI PGIMSR, Basaidarapur, Delhi, India

Correspondence Address:
Sweta Kumari
Department of Pediatrics, ESI PGIMSR, Basaidarapur, Delhi - 110 015
India

Objective: This study was planned to study serum cystatin C (CysC) levels in sick neonates admitted in neonatal intensive care unit (NICU) with predisposing risk factor(s) for development of acute kidney injury (AKI). We evaluated serum levels of CysC and creatinine in sick neonates. Methods: Ninety-four sick neonates with prematurity, sepsis, respiratory distress, and/or perinatal asphyxia requiring NICU admission were enrolled. Serum levels of creatinine and CysC were measured on day 3 of life. Results: Serum levels of both cystatin C and creatinine were significantly elevated in neonates who developed AKI versus those who did not (CysC: 2.18 ± 0.59 vs. 1.91 ± 0.47 mg/dl, P = 0.04; creatinine: 1.68 ± 0.75 vs. 0.89 ± 0.40, P < 0.001). Levels of CysC were elevated in sick neonates with risk factors of developing AKI. Conclusions: Serum levels of CysC are elevated in sick neonates at risk of AKI. CysC is a useful indicator of risk of AKI in ill neonates.


How to cite this article:
Bagla J, Kumari S, Gupta R, Khan I. Cystatin C as a biomarker of acute kidney injury in sick neonates.Asian J Pediatr Nephrol 2020;3:10-14


How to cite this URL:
Bagla J, Kumari S, Gupta R, Khan I. Cystatin C as a biomarker of acute kidney injury in sick neonates. Asian J Pediatr Nephrol [serial online] 2020 [cited 2020 Oct 22 ];3:10-14
Available from: https://www.ajpn-online.org/article.asp?issn=2589-9309;year=2020;volume=3;issue=1;spage=10;epage=14;aulast=Bagla;type=0